Saturday, 15 September 2018

Your current reality is an accumulation of the thoughts you've been thinking in the past.

Wednesday, 18 July 2018

Neem (Azadirachta indica)

Neem (Azadirachta indica) is a member of the Meliaceae family and its role as health-promoting effect is attributed because it is rich source of antioxidant. It has been widely used in Chinese, Ayurvedic, and Unani medicines worldwide especially in Indian Subcontinent in the treatment and prevention of various diseases. Earlier finding confirmed that neem and its constituents play role in the scavenging of free radical generation and prevention of disease pathogenesis. The studies based on animal model established that neem and its chief constituents play pivotal role in anticancer management through the modulation of various molecular pathways including p53, pTEN, NF-κB, PI3K/Akt, Bcl-2, and VEGF. It is considered as safe medicinal plants and modulates the numerous biological processes without any adverse effect.

Azadirachta indica L. (neem) shows therapeutics role in health management due to rich source of various types of ingredients. The most important active constituent is azadirachtin and the others are nimbolinin, nimbin, nimbidin, nimbidol, sodium nimbinate, gedunin, salannin, and quercetin. Leaves contain ingredients such as nimbin, nimbanene, 6-desacetylnimbinene, nimbandiol, nimbolide, ascorbic acid, n-hexacosanol and amino acid, 7-desacetyl-7-benzoylazadiradione, 7-desacetyl-7-benzoylgedunin, 17-hydroxyazadiradione, and nimbiol. Quercetin and ß-sitosterol, polyphenolic flavonoids, were purified from neem fresh leaves and were known to have antibacterial and antifungal properties and seeds hold valuable constituents including gedunin and azadirachtin.

Possible mechanism of action of Azadirachta indica is presented as follows.

Neem (Azadirachta indica) plants parts shows antimicrobial role through inhibitory effect on microbial growth/potentiality of cell wall breakdown. Azadirachtin, a complex tetranortriterpenoid limonoid present in seeds, is the key constituent responsible for both antifeedant and toxic effects in insects. Results suggest that the ethanol extract of neem leaves showed in vitro antibacterial activity against bothStaphylococcus aureus and MRSA with greatest zones of inhibition noted at 100% concentration.
  1. Neem plays role as free radical scavenging properties due to rich source of antioxidant. Azadirachtin and nimbolide showed concentration-dependent antiradical scavenging activity and reductive potential in the following order: nimbolide > azadirachtin > ascorbate. 
  2. Neem ingredient shows effective role in the management of cancer through the regulation of cell signaling pathways. Neem modulates the activity of various tumour suppressor genes (e.g., p53, pTEN), angiogenesis (VEGF), transcription factors (e.g., NF-κB), and apoptosis (e.g., bcl2, bax). 
  3. Neem also plays role as anti-inflammatory via regulation of proinflammatory enzyme activities including cyclooxygenase (COX), and lipoxygenase (LOX) enzyme.

Tuesday, 15 May 2018

When adults say, "Teenagers think they are invincible" with that sly, stupid smile on their faces, they don't know how right they are. We need never be hopeless, because we can never be irreparably broken. We think that we are invincible because we are. We cannot be born, and we cannot die. Like all energy, we can only change shapes and sizes and manifestations. They forget that when they get old. They get scared of losing and failing. But that part of us greater than the sum of our parts cannot begin and cannot end, and so it cannot fail.

Sunday, 6 May 2018

Don't listen to them - go for it. Take your time. Find what you need. Then do the work that needs to be done.

Dear me... To remember who you are, you must let go of who they told you to be.

It felt like the end, but it was really the start.

Maybe to truly find your way you must first fully accept that terrifying feeling of feeling lost.

I want to be awake, not just alive.

Dear me... It's so easy to blame everything else other than yourself.

Wednesday, 4 April 2018

神様なんていないと思っていたけど、いるなら君のことだろう。

Tuesday, 20 March 2018

Failures are our greatest teachers. You will fail. It's just how it is and there is nothing that you can do to stop that. It's what do you after that will define where you go.

Monday, 19 March 2018

Change your life



All great leaders have learned how to hack their consciousness and they all point us within.
But the fear that scares me most is that we continue to sleepwalk during our short time here on Earth never truly waking up to make our dreams a reality.
We can choose to be more aware, more responsible, more conscious.
Becoming more conscious, more aware, more awaken means starting to look for the truth within yourself, means gaining mastery over your fears that have blocked your most important life experiences that you've been missing out on until now.